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Drug intelligence / Profile preview
betulonic acid
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral, Topical, Intravenous, Transdermal, Rectal, Intranasal, Intramuscular, Intraperitoneal, Subcutaneous
01
Overview
Betulonic acid is a naturally occurring lupane-type pentacyclic triterpenoid, primarily derived from the bark of birch trees (*Betula* species). Structurally, it is the 3-oxo analog of betulinic acid, featuring a ketone group at the C-3 position instead of a hydroxyl group. It is widely utilized in preclinical research due to its diverse biological activities, which include anti-tumor, anti-viral, anti-inflammatory, anti-bacterial, and hepatoprotective properties. Despite its pharmacological potential and its role as a chemical intermediate for the synthesis of more potent semisynthetic derivatives with improved bioavailability, betulonic acid has not been advanced into clinical trials by any pharmaceutical developer and remains a research compound.
- Other names
- 3-oxolup-20(29)-en-28-oic acid3-ketobetulinic acidliquidambaric acid
02
Targets
ABCB1 (P-glycoprotein)ABCB5 (ATP-binding cassette sub-family B member 5)ABCG2 (Breast cancer resistance protein)E3 ligase (E3 ubiquitin ligases)PPARA (Peroxisome proliferator-activated receptor alpha)RXRA (Retinoid X receptor alpha)TRAF2
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