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bevacizumab + capecitabine + erlotinib + oxaliplatin

Development stage: Unknown
Lead developer: Genentech
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous, Oral

Overview

A combination therapy regimen consisting of bevacizumab (a monoclonal antibody targeting VEGF-A), capecitabine (an oral fluoropyrimidine), erlotinib (an EGFR tyrosine kinase inhibitor), and oxaliplatin (a platinum-based chemotherapy agent). This regimen has been studied in phase II clinical trials for metastatic colorectal cancer, typically administered as an induction phase with bevacizumab, capecitabine, and oxaliplatin (XELOX) followed by a maintenance phase with bevacizumab plus erlotinib.

Targets

EGFR T790M (Epidermal growth factor receptor T790M mutant)VEGFA (Vascular endothelial growth factor A)DNATS (Thymidylate synthase)

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