Drug intelligence / Profile preview

bevacizumab + carboplatin + fosbretabulin + paclitaxel

Development stage
Phase 2
Lead developer
Oncotelic Therapeutics
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

A combination therapy consisting of bevacizumab, carboplatin, fosbretabulin, and paclitaxel. Bevacizumab is an antibody that works by decreasing blood supply to tumors. Carboplatin is a platinum-containing compound that attacks fast-growing cancer cells. Paclitaxel is a chemotherapy agent that disrupts cell division. Fosbretabulin (combretastatin A4 phosphate) is a vascular disrupting agent. This combination may be used in the treatment of various cancers.

Other names
BCP plus fosbretabulin tromethamine
02

Targets

DNATUBB (Tubulin (alpha and beta subunits))VEGFA (Vascular endothelial growth factor A)

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