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Bevacizumab + Cisplatin + Vinorelbine

Development stage: Unknown
Lead developer: Genentech
Modality: Nucleic Acid-Directed Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Intravenous

Overview

Bevacizumab + cisplatin + vinorelbine is a combination chemotherapy regimen that combines an anti-angiogenic monoclonal antibody with two cytotoxic agents. This regimen has been evaluated in Phase II clinical trials for the treatment of non-squamous non-small cell lung cancer (NSCLC)[1][4]. The treatment typically consists of 3-week cycles with bevacizumab (15 mg/kg on day 1), cisplatin (80 mg/m² on day 1), and vinorelbine (25 mg/m² on days 1 and 8)[1]. After completing 6 cycles of the combination therapy, non-progressing patients may continue with bevacizumab maintenance therapy[1].

Other names: bevacizumab + vinorelbine + cisplatin

Targets

DNATUBB (Tubulin (alpha and beta subunits))VEGFA (Vascular endothelial growth factor A)

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