Drug intelligence / Profile preview

bevacizumab + eribulin

Development stage
Unknown
Lead developer
Eisai
Modality
Nucleic Acid-Directed Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Intravenous
01

Overview

Bevacizumab + eribulin is a combination therapy used primarily in the treatment of HER2-negative metastatic breast cancer. Bevacizumab is a monoclonal antibody that inhibits vascular endothelial growth factor A (VEGF-A), thereby blocking angiogenesis and reducing tumor blood supply. Eribulin is a synthetic analog of halichondrin B and acts as a microtubule dynamics inhibitor; it binds to the plus ends of microtubules, suppressing their polymerization and extension without affecting depolymerization, leading to cell cycle arrest at G2/M phase and apoptosis. This combination has been studied in both first-line and second-line settings for metastatic breast cancer patients who have progressed after prior therapies[1][2][3][6].

Other names
bevacizumab + eribulinAvastin + Halaven
02

Targets

TUBB (Tubulin (alpha and beta subunits))VEGFA (Vascular endothelial growth factor A)

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