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bevacizumab + everolimus + temozolomide
- Development stage
- Unknown
- Lead developer
- Genentech
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
A combination therapy consisting of bevacizumab (a VEGF inhibitor), everolimus (an mTOR inhibitor), and temozolomide (an alkylating agent). This regimen has been studied in the treatment of glioblastoma, where it is administered with radiation therapy followed by maintenance therapy. The combination targets multiple pathways involved in cancer progression: angiogenesis (bevacizumab), cell survival signaling (everolimus), and DNA damage (temozolomide).
02
Targets
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