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bevacizumab + nab-paclitaxel + tegafur gimeracil oteracil potassium
- Development stage
- Unknown
- Lead developer
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This investigational combination regimen consists of bevacizumab, nab-paclitaxel (albumin-bound paclitaxel), and S-1 (a combination of tegafur, gimeracil, and oteracil potassium). Bevacizumab is a recombinant humanized monoclonal antibody that acts as an anti-angiogenic agent by binding to vascular endothelial growth factor (VEGF), preventing its interaction with receptors on endothelial cells. Nab-paclitaxel is a taxane chemotherapy agent that stabilizes microtubules, thereby inhibiting cell division. S-1 is an oral fluoropyrimidine chemotherapy that includes tegafur (a prodrug of 5-fluorouracil), gimeracil (which inhibits the degradation of 5-FU), and oteracil potassium (which reduces gastrointestinal toxicity). This triplet regimen is being evaluated as a second-line therapy for patients with advanced biliary tract adenocarcinoma who have progressed on or are intolerant to first-line treatments.
- Brand names
- TS-1TS1TS 1Teysuno
- Other names
- bevacizumab + nab-paclitaxel + S-1bevacizumab + nab-paclitaxel + tegafur gimeracil oteracil potassium capsule
02
Targets
DPYD (Dihydropyrimidine dehydrogenase)VEGFA (Vascular endothelial growth factor A)TS (Thymidylate synthase)TUBB (Tubulin (alpha and beta subunits))
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