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bevacizumab + panitumumab

Development stage: Unknown
Lead developer: Genentech
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous

Overview

A combination of two monoclonal antibodies with different targeting mechanisms used in the treatment of metastatic colorectal cancer (mCRC). Bevacizumab targets vascular endothelial growth factor (VEGF), while panitumumab targets epidermal growth factor receptor (EGFR). This combination has been studied with chemotherapy regimens such as FOLFIRI (irinotecan, 5-fluorouracil, and leucovorin) as a treatment option for patients with mCRC.

Targets

EGFR T790M (Epidermal growth factor receptor T790M mutant)VEGFA (Vascular endothelial growth factor A)

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