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bevacizumab + pegylated liposomal doxorubicin
- Development stage
- Unknown
- Lead developer
- Genentech
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
A combination therapy consisting of bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor (VEGF), and pegylated liposomal doxorubicin (PLD), a modified form of the chemotherapy drug doxorubicin. Bevacizumab works by inhibiting angiogenesis, reducing blood vessel formation that supplies tumors with nutrients and oxygen. Pegylated liposomal doxorubicin is doxorubicin encapsulated in liposomes and treated with polyethylene glycol, which allows the drug to remain in circulation longer and increases delivery to tumor sites while reducing toxicity to normal tissues.
- Brand names
- DoxilCaelyx
- Other names
- bevacizumab and pegylated liposomal doxorubicinbevacizumab and Doxilbevacizumab and Caelyx
02
Targets
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