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bexarotene + methoxsalen
- Development stage
- Unknown
- Lead developer
- Ligand Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral, Topical, Parenteral
01
Overview
Bexarotene + methoxsalen is a combination therapy primarily utilized in the management of advanced or refractory cutaneous T-cell lymphoma (CTCL), including mycosis fungoides and Sézary syndrome. Bexarotene is a synthetic retinoid that selectively activates retinoid X receptors (RXRs), which function as transcription factors regulating cell differentiation and apoptosis. Methoxsalen is a photoactive compound (psoralen) that, when activated by ultraviolet A (UVA) light (PUVA therapy) or used in extracorporeal photopheresis (ECP), forms DNA cross-links to inhibit cell proliferation and induce apoptosis in malignant T-cells. The combination is often employed to enhance clinical response in patients who have failed monotherapy, leveraging the synergistic effects of RXR activation and DNA-targeted photochemotherapy.
- Brand names
- Oxsoralen
- Other names
- bexarotene and methoxsalenmethoxsalen and bexarotene
02
Targets
RXRA (Retinoid X receptor alpha)PPARG (Peroxisome proliferator-activated receptor gamma)
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