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BG129
- Development stage
- Preclinical
- Lead developer
- Merrimack Pharmaceuticals
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
BG129 is a novel small molecule inhibitor of Ataxia telangiectasia and Rad3-related (ATR) protein kinase, a key regulator of the DNA damage response (DDR) pathway. Developed by Merrimack Pharmaceuticals, BG129 is designed to be used in combination with DNA-damaging agents, such as carboplatin, gemcitabine, or irinotecan, to enhance their anti-tumor activity by blocking DNA repair mechanisms in cancer cells. To address the rapid clearance observed with early ATR inhibitors, BG129 was formulated into nano-liposomes (nLs-BG129). This formulation significantly improves the pharmacokinetic profile, providing prolonged clearance and enhanced efficacy in preclinical models of ovarian and lung cancers.
- Other names
- nLs-BG129nLs-BG-129nLs-BG 129
02
Targets
ATR (ATR serine/threonine kinase)
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