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BG505 SOSIP GT1.1 gp140
- Development stage
- Phase 1
- Lead developer
- International AIDS Vaccine Initiative
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
BG505 SOSIP GT1.1 gp140 is an experimental HIV-1 vaccine candidate designed as a soluble, cleavage-competent trimeric envelope glycoprotein (gp140) based on the HIV-1 strain BG505 and engineered for germline-targeting to elicit broadly neutralizing antibody (bnAb) precursors against conserved epitopes of the virus[3][4][6]. The vaccine is administered intramuscularly and formulated with an adjuvant to enhance immune response[3][5]. It aims to induce B cell responses capable of maturing into protective bnAbs by targeting the CD4 binding site (CD4bs) and other conserved regions on the HIV envelope protein[4][6]. The immunogen was developed using structure-based design approaches to optimize its ability to engage diverse naive B cell receptors relevant for bnAb development[4][6]. Primary indication is prevention of HIV infection.
- Other names
- BG505 SOSIP.GT1.1BG-505 SOSIP.GT1.1BG 505 SOSIP.GT1.1GT1.1GT-1.1GT 1.1
02
Targets
BCR-HIV-Env (HIV-1 envelope-specific B-cell receptor)
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