Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
BGB-B455
- Development stage
- Phase 1
- Lead developer
- BeOne Medicines
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
BGB-B455 is a bispecific antibody developed by BeiGene that targets claudin 6 (CLDN6) on tumor cells and the CD3 receptor on T cells. By binding to both CLDN6, which is preferentially expressed in certain tumors, and CD3 on T cells, BGB-B455 acts as an immune cell engager designed to promote a CLDN6-dependent antitumor immune response. This mechanism aims to enhance the immune system's ability to attack cancer cells while minimizing systemic toxicity. The drug is currently being investigated for use in patients with advanced or metastatic solid tumors expressing CLDN6[1][2][4][5][7][8].
- Other names
- CLDN6 x CD3 bispecific antibodyCLDN-6 x CD3 bispecific antibodyCLDN 6 x CD3 bispecific antibodyClaudin-6 x CD3 bispecific antibodyClaudin6 x CD3 bispecific antibodyClaudin 6 x CD3 bispecific antibody
02
Targets
CLDN6 (Claudin-6)CD3 (T-cell surface glycoprotein CD3)
Beyond the preview
Go deeper on BGB-B455.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on BGB-B455.