BH-015

BH-015 is a small molecule inhibitor of **Ubiquitin-specific protease 15 (USP15)**, a deubiquitinating enzyme (DUB) that plays a critical role in various cellular processes, including the TGF-β signaling pathway, DNA repair, and protein trafficking. By inhibiting USP15, BH-015 promotes the degradation of USP15 substrates, such as TGF-β receptor I (TβRI) and other oncogenic proteins, thereby suppressing tumor growth and progression. Preclinical research has demonstrated its potential in inhibiting the growth of various cancer types, including gastric cancer and glioblastoma, by modulating the stability of key signaling molecules and inducing apoptosis and cell cycle arrest. It is primarily utilized as a pharmacological tool in laboratory research to investigate the biological functions of USP15 and its potential as a therapeutic target in oncology.