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BHV-1450

Development stage: Preclinical
Lead developer: Biohaven
Modality: PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules

Overview

BHV-1450 is a drug candidate being developed by Biohaven Pharmaceuticals. It is an IgG4 specific MoDE (Molecular Degraders of Extracellular Proteins) degrader, part of Biohaven's proprietary platform technology licensed from Yale University. This platform is designed to create extracellular degraders that selectively remove specific disease-causing proteins. BHV-1450 is being investigated for potential indications such as pemphigus vulgaris and myasthenia gravis with anti-MuSK antibodies, aiming to treat a range of autoimmune diseases by targeting and degrading pathogenic IgG4 antibodies.

Targets

IgG4 (Immunoglobulin G4)

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