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BI 1815368 + itraconazole
- Development stage
- Unknown
- Lead developer
- Boehringer Ingelheim
- Modality
- Peptides, Small Molecules
- Administration
- Subcutaneous, Oral
01
Overview
BI 1815368 + itraconazole is an investigational drug combination used in clinical pharmacology studies to evaluate drug-drug interactions. **BI 1815368** is a long-acting peptide-based dual agonist of the glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptors, developed by Boehringer Ingelheim for the treatment of obesity and metabolic disorders. **Itraconazole** is a potent triazole antifungal agent that serves as a strong inhibitor of the cytochrome P450 3A4 (CYP3A4) enzyme and the P-glycoprotein (P-gp) efflux transporter. The combination is primarily studied to determine the impact of strong CYP3A4 and P-gp inhibition on the pharmacokinetics, safety, and tolerability of BI 1815368, ensuring that its metabolic and transport pathways are well-characterized for clinical use.
- Other names
- BI 1815368 and itraconazoleBI1815368 and itraconazoleBI-1815368 and itraconazole
02
Targets
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