Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
BI 730357 + itraconazole
- Development stage
- Unknown
- Lead developer
- Boehringer Ingelheim
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
BI 730357 + itraconazole is a **combination of BI 730357, an oral small molecule inhibitor of the retinoic acid-related orphan receptor gamma t (RORγt), and itraconazole, a triazole antifungal agent**. BI 730357 is investigated primarily for moderate-to-severe plaque psoriasis and psoriatic arthritis. Its mechanism involves selective inhibition of RORγt, a key transcription factor promoting pathogenic Th17 cell differentiation and interleukin-17 production, which are implicated in autoimmune diseases like psoriasis[1][3][4][6]. Itraconazole acts by inhibiting the fungal enzyme lanosterol 14α-demethylase, blocking ergosterol synthesis and thus compromising the fungal cell membrane[2]. This combination has been studied in phase 1 pharmacokinetic and drug-drug interaction trials to assess potential effects of itraconazole on BI 730357 metabolism[4].
- Other names
- BI 730357 + itraconazole
02
Targets
RORγt
Beyond the preview
Go deeper on BI 730357 + itraconazole.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on BI 730357 + itraconazole.