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bi-SNA
- Development stage
- Preclinical
- Lead developer
- Northwestern University
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Intradermal, Transdermal
01
Overview
bi-SNA (bimodal Spherical Nucleic Acid) is an experimental nanotherapeutic platform designed for the treatment of glioblastoma (GBM) and other high-grade gliomas. It consists of a 15-nm gold nanoparticle core functionalized with a dense shell of hairpin oligonucleotides that incorporate STAT3-decoy sequences. This bimodal design enables the simultaneous activation of the cyclic GMP-AMP synthase (cGAS) pathway to stimulate innate immunity and the sequestration of Signal Transducer and Activator of Transcription 3 (STAT3) to inhibit oncogenic signaling and immune suppression. To overcome the blood-brain barrier (BBB), bi-SNA is delivered via a novel facial dermal iontophoresis system that leverages facial neuro-lymphatic and neuronal pathways (such as the trigeminal and olfactory routes) for targeted brain delivery, bypassing systemic exposure.
- Other names
- bimodal spherical nucleic acidbimodal SNA
02
Targets
STAT3 (Signal Transducer and Activator of Transcription 3)MSR1 (Amyloid beta precursor protein binding family B member 3)Cyclic GMP–AMP synthase
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