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BI0106 ADC
- Development stage
- Unknown
- Lead developer
- Protheragen
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
BI0106 ADC is an antibody-drug conjugate (ADC) developed by Protheragen, currently in Phase I clinical development for the treatment of solid tumors. The agent specifically targets Trophoblast cell-surface antigen 2 (Trop-2), a transmembrane glycoprotein that is frequently overexpressed in a variety of epithelial cancers, including breast, lung, and gastric malignancies. BI0106 ADC is designed to bind to Trop-2 on the surface of tumor cells, leading to internalization and the subsequent release of a cytotoxic payload to induce targeted cell death while minimizing systemic exposure. The program is listed as an available project for licensing and further development by the sponsor.
- Other names
- Trop-2 ADCTrop2 ADCTrop 2 ADC
02
Targets
TUBB (Tubulin (alpha and beta subunits))TACSTD2 (Tumor-associated calcium signal transducer 2)
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