BIA 5-1058 + furosemide

**BIA 5-1058 + furosemide** is a combination drug regimen investigated primarily for the treatment of pulmonary arterial hypertension (PAH). **BIA 5-1058**, also known as **zamicastat**, is an experimental small molecule developed to modulate cardiovascular disease by inhibiting dopamine beta-hydroxylase (DBH), resulting in reduced sympathetic nervous system activity[3][5]. **Furosemide** is a well-established loop diuretic primarily used to treat edema and hypertension by inhibiting sodium and chloride reabsorption in the kidney's loop of Henle[7]. The combination is investigated because PAH often requires both modulation of sympathetic activity and management of associated edema.

Other names

BIA 5-1058 + furosemidezamicastat + furosemide