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BIBR 1048 MS Capsule I
- Development stage
- Unknown
- Lead developer
- Boehringer Ingelheim
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
BIBR 1048 MS Capsule I is an experimental oral capsule formulation of dabigatran etexilate (BIBR 1048), a small-molecule prodrug developed by Boehringer Ingelheim. Upon oral administration, dabigatran etexilate is rapidly converted by endogenous esterases into its active form, dabigatran (BIBR 953 ZW). Dabigatran is a potent, nonpeptidic, direct and reversible thrombin (Factor IIa) inhibitor that prevents the conversion of fibrinogen to fibrin, thereby inhibiting thrombus formation. BIBR 1048 MS Capsule I was specifically evaluated in Phase 1 clinical trials to assess its bioavailability and pharmacokinetic profile in healthy subjects, including investigations into the impact of co-administered proton pump inhibitors like pantoprazole on its absorption.
- Other names
- BIBR 1048 MS Capsule 1BIBR1048 MS Capsule 1BIBR-1048 MS Capsule 1
02
Targets
F2 (Thrombin)
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