Drug intelligence / Profile preview

bicalutamide + calcium + vitamin D

Development stage
Unknown
Lead developer
AstraZeneca
Modality
Small Molecules
Administration
Oral
01

Overview

The combination of bicalutamide, calcium, and vitamin D is a therapeutic regimen primarily used in the management of prostate cancer. Bicalutamide is a non-steroidal anti-androgen (NSAA) that acts as a competitive antagonist of the androgen receptor, thereby inhibiting the growth of androgen-sensitive prostate tumors. Because androgen deprivation therapy (ADT) is associated with a significant risk of bone mineral density loss and subsequent osteoporosis or fractures, calcium and vitamin D are co-administered as essential supportive care. Calcium serves as a structural component for bone mineralization, while vitamin D facilitates calcium absorption and maintains bone homeostasis. This regimen is standard clinical practice to mitigate the skeletal side effects of long-term hormonal therapy in prostate cancer patients.

Other names
bicalutamide plus calcium and vitamin Dbicalutamide, calcium, and vitamin D
02

Targets

VDR (Vitamin D receptor)AR (Adrenergic receptors)

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