bicarbonate dialysate-NYU Langone Health

Bicarbonate dialysate-NYU Langone Health refers to a modified hemodialysis solution and procedure being investigated by NYU Langone Health for patients with end-stage renal disease. The intervention, termed 'isohydric hemodialysis', involves adjusting the sodium bicarbonate concentration in the dialysate fluid—specifically starting at a lower concentration (25 mmol/L) for the first half of the treatment before switching to a standard concentration (37 mmol/L). This approach aims to manipulate the pH-dependent binding of protein-bound uremic retention solutes, such as indoxyl sulfate, to albumin. By altering the pH environment, the treatment seeks to increase the free fraction of these toxins, thereby enhancing their removal during filtration, which is typically inefficient under standard dialysis conditions.

Other names

low bicarbonate dialysatenormal bicarbonate dialysateisohydric hemodialysis solution