Drug intelligence / Profile preview

bichromate tromethamine

Development stage
Unknown
Lead developer
Roche
Modality
Small Molecules
Administration
Intravenous, Intramuscular, Oral, Ophthalmic
01

Overview

Bichromate tromethamine is a non-existent chemical entity that appears as a systematic mistranslation of **ketorolac tromethamine** (酮咯酸氨基丁三醇) in the English-language records of several clinical trials registered in the Chinese Clinical Trial Registry (ChiCTR), including ChiCTR2100042389. Ketorolac tromethamine is a potent non-steroidal anti-inflammatory drug (NSAID) of the heterocyclic acetic acid derivative class. It exerts its analgesic, anti-inflammatory, and antipyretic effects by non-selectively inhibiting the cyclooxygenase enzymes COX-1 and COX-2, thereby blocking the conversion of arachidonic acid into pro-inflammatory prostaglandins. Clinically, it is used for the short-term management of moderate to severe acute pain, often as an alternative or adjunct to opioids in postoperative settings. In the context of augmentation mammoplasty, it is typically administered intravenously as part of a multimodal analgesia regimen. The erroneous name bichromate tromethamine likely arises from a translation artifact where the characters for ketorolac (酮咯) were misidentified as those for bichromate (重铬); bichromate is a toxic inorganic salt and is not used as a pharmaceutical ingredient.

Other names
bichromate tromethamineketorolac tromethamine
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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