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BicycleTx TSLP compound Bicycle 46: sourced facts only. name: "This resulted in the potent Bicycle 46 with nanomolar affinity to TSLP (KD = 13 nM), low plasma clearance of 6.4 mL/min/kg, and an effective half-life of 46 min after intravenous dosing to rats." [PMID:38284169]; target: "This resulted in the potent Bicycle 46 with nanomolar affinity to TSLP (KD = 13 nM), low plasma clearance of 6.4 mL/min/kg, and an effective half-life of 46 min after intravenous dosing to rats." [PMID:38284169]; developer: "BicycleTx Limited, Portway Building, Granta Park, Cambridge CB21 6GS, U.K." [PMID:38284169]; modality: "Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin." [PMID:38284169]
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