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bidens pilosa
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Bidens pilosa is a medicinal plant commonly used in traditional Chinese medicine and other herbal systems. The name "复方鬼针草颗粒模拟剂" refers to a simulated (placebo) granule formulation used as a control in clinical trials for the compound preparation "复方鬼针草颗粒", which contains Bidens pilosa as one of its main ingredients. Bidens pilosa itself is known for its anti-inflammatory, antihypertensive, immunomodulatory, and antioxidant properties. Its mechanism of action involves multiple targets and pathways including modulation of vascular endothelial growth factor A (VEGFA), RAC-alpha serine/threonine-protein kinase (AKT1), interleukin-6 (IL-6), tumor necrosis factor (TNF), and related signaling pathways such as TNF signaling, HIF-1 signaling, cGMP-PKG pathway, PI3K-Akt pathway, and Toll-like receptor pathway. These actions contribute to effects on blood pressure regulation, inflammation reduction, cell proliferation inhibition, apoptosis modulation, and immune response[4].
- Other names
- 复方鬼针草颗粒模拟剂Bidens pilosaSpanish needle
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)VEGFA (Vascular endothelial growth factor A)TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)
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