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Drug intelligence / Profile preview
Bidiol
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Bidiol is a branded cannabis-derived product containing cannabidiol (CBD), a non-intoxicating phytocannabinoid from Cannabis sativa that exerts anticonvulsant, analgesic, anti-inflammatory, anxiolytic, and neuroprotective effects through complex modulation of the endocannabinoid system and multiple non-cannabinoid targets. Cannabidiol displays low affinity for CB1 and CB2 cannabinoid receptors and instead acts as a negative allosteric modulator at CB1, an antagonist at the orphan G protein–coupled receptor GPR55, and a modulator of intracellular calcium flux and various neurotransmitter systems, including serotonin, dopamine, and GABAergic signaling, which together are thought to underlie its seizure‑reducing and symptom‑modifying activity in certain neurologic conditions.[3][5][9][10]
- Brand names
- Bidiol
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))ADRA1A (α1A)CNR1 (Cannabinoid receptor 1)GABRR (GABA-A receptor subunit rho)GPR55 (G protein-coupled receptor 55)MOR (Mu opioid receptor)TRPV1 (Transient receptor potential cation channel subfamily V member 1)
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