Bietaserpine

Bietaserpine is a small molecule drug and a derivative of reserpine, identified by code names such as DL 152 and N-diethylaminoethyl reserpine. It was investigated as an antihypertensive agent and also exhibited sedative effects. Its mechanism of action involves the inhibition of vesicular monoamine transporters (VMAT1 and VMAT2), similar to its parent compound reserpine. This inhibition leads to the depletion of monoamine neurotransmitters, including norepinephrine, dopamine, and serotonin, from synaptic vesicles. The resulting reduction in sympathetic nervous system activity contributes to its hypotensive effects.

Other names

N-diethylaminoethyl reserpine1-[2-(diethylamino)ethyl]reserpine