bifendate

Bifendate is a synthetic small molecule derivative of schisandrin C, developed on the basis of the hepatoprotective ingredients from *Schisandra chinensis*. It is primarily used to lower alanine transaminase (ALT) and treat chronic hepatitis, particularly chronic persistent hepatitis accompanied by elevated ALT. Bifendate acts as a membrane stabilizer and protects liver cells from damage. Mechanistically, it is considered a **potent inducer of cytochrome P450 enzymes**—especially CYP3A4—via a pregnane X receptor (PXR)-dependent pathway, thereby stimulating drug-metabolizing activities (e.g., glutathione peroxidase, glutathione reductase, glutathione-S-transferase). Bifendate can alter the pharmacokinetics of other drugs metabolized by CYP3A4, most notably decreasing cyclosporine concentrations in a genotype-dependent manner. It has also been explored for its effects on serum and hepatic lipid metabolism as well as in combination therapies for cancer models.

Brand names

Bifendate Pills

Other names

diphenyl dimethyl bicarboxylatedimethyl dicarboxylate biphenylmethyl 7-methoxy-4-(7-methoxy-5-methoxycarbonyl-1,3-benzodioxol-4-yl)-1,3-benzodioxole-5-carboxylateBIFENDATATUMBIFENDATATUM (B.D.D)Bifendatatum CP