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Drug intelligence / Profile preview
bifidobacterium adolescentis bif-038
- Development stage
- Preclinical
- Lead developer
- Novonesis
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
**Bifidobacterium adolescentis bif-038** is a probiotic strain of Bifidobacterium adolescentis, a Gram-positive, anaerobic, non-spore-forming bacterial species naturally present in the human gut[1][4]. The strain DSM 29103 (also called BIF-038) is characterized by its ability to improve intestinal barrier function (evidenced by increasing trans-epithelial electrical resistance in Caco-2 cells) and to elicit a strong anti-inflammatory immune response (inducing secretion of >200 pg/ml of the anti-inflammatory cytokine IL-10 and raising the IL-10:IL-12 ratio >1 in dendritic cells)[2]. Mechanistically, these effects involve modulation of the immune response and enhancement of epithelial barrier integrity. B. adolescentis strains also metabolize resistant starch and other plant-derived glycans, producing acetate and lactate as main metabolites. The strain is under investigation for potential benefit in conditions with impaired intestinal barrier or chronic inflammation, such as IBD, IBS, metabolic syndrome, diabetes, obesity, NAFLD, NASH, autoimmune conditions, and some mood or cognitive disorders[2][1][3].
- Brand names
- Bif-038Bif038Bif 038
- Other names
- bifidobacterium adolescentis DSM 29103
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