Drug intelligence / Profile preview

Bifidobacterium adolescentis PRL2019

Development stage
Preclinical
Lead developer
Pharmextracta
Modality
Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Gabapral is a probiotic food supplement containing the bacterial strain Bifidobacterium adolescentis PRL2019. Developed by Pharmextracta, it is designed to support the gut-brain axis by producing gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the mammalian central nervous system. Gabapral is indicated for the management of irritable bowel syndrome (IBS), particularly in pediatric patients, and has also been associated with potential benefits for stress, anxiety, and insomnia. By increasing GABA levels in the gut, it helps regulate gut motility, reduce visceral hypersensitivity, and alleviate recurrent abdominal pain.

Brand names
GABApral
Other names
B. adolescentis PRL2019
02

Targets

GABRR (GABA-A receptor subunit rho)GABA-B (Gamma-aminobutyric acid receptor type B)

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