bifidobacterium animalis ssp. lactis 420 + lacticaseibacillus rhamnosus hn001

This is a combination probiotic product containing two well-characterized strains: *Bifidobacterium animalis* subsp. *lactis* 420 and *Lacticaseibacillus rhamnosus* HN001 (formerly known as *Lactobacillus rhamnosus* HN001). Both are non-pathogenic, lactic acid-producing bacteria used as probiotics to support gastrointestinal health and modulate immune function. **Mechanism of Action:** The strains act primarily by colonizing the gut, producing lactic and acetic acids that lower intestinal pH, inhibiting pathogenic bacteria, supporting mucosal barrier integrity, and modulating host immune responses through increased IgA secretion and cytokine modulation[3][5][6]. The combination has been studied for its potential to reduce the risk of atopic diseases such as eczema in infants when administered during pregnancy and early life[4][8], with additional evidence for benefits in gut health, including improved intestinal barrier function. **Primary Indications:** The main indications under investigation or use include prevention of eczema/atopic dermatitis in infants at high risk[4][8], general support for gastrointestinal health, modulation of immune responses, reduction of potentially harmful gut bacteria populations[1], and possible adjunctive effects on oral inflammation.

Brand names

howaru protect earlylifehowaru rhamnosushowaru bifido

Other names

bifidobacterium lactis 420 + lactobacillus rhamnosus hn001b. animalis subsp. lactis 420 + l. rhamnosus hn001