Drug intelligence / Profile preview

bifidobacterium bifidum R0071

Development stage
Preclinical
Lead developer
Lallemand Health Solutions
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Bifidobacterium bifidum R0071, also known as Rosell-71, is a specific strain of probiotic bacteria developed and manufactured by Lallemand Health Solutions. [15] It is a gram-positive, anaerobic bacterium naturally found in the human colon, especially in newborns. [15] The strain is well-documented and has been investigated in numerous clinical trials, often as part of multi-strain synbiotic formulations. For example, it is a component of Lallemand's Probiokid® formulation, which also includes other probiotic strains and fructooligosaccharides. [7, 13] B. bifidum R0071 functions by modulating the gut microbiome, adhering to intestinal cells, creating a barrier effect against pathogens, and regulating the host's immune system by reducing pro-inflammatory responses. [15] Clinical studies have explored its efficacy in various areas, including the prevention of allergic diseases in infants, management of symptoms in connective tissue diseases, irritable bowel syndrome, and post-operative Crohn's disease. [1, 2, 3, 4, 5] Research has also shown its potential to reduce the incidence of cold/flu and alleviate stress-associated gastrointestinal symptoms in healthy adults. [17, 18] The strain has achieved Generally Recognized as Safe (GRAS) status from the U.S. FDA and is approved for use in infant formulas in several countries, including China and Canada, highlighting its safety profile. [7, 11]

Other names
Bifidobacterium bifidum Rosell-71

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