Bifidobacterium breve BR03 + Lactobacillus salivarius LS01

The combination of Bifidobacterium breve BR03 and Lactobacillus salivarius LS01 is a probiotic formulation that has been studied for various health conditions, particularly those related to immune modulation and inflammation. ## Composition and Characteristics This probiotic combination consists of two specific bacterial strains: 1. **Bifidobacterium breve BR03 (DSM 16604)** - A beneficial bacteria that lives in the intestines and produces lactic and acetic acid in the gut[3]. 2. **Lactobacillus salivarius LS01** - A probiotic strain that has shown antipathogenic properties, particularly against Staphylococcus aureus, and possesses antioxidant activity[8]. ## Therapeutic Applications The BR03 + LS01 combination has been studied for several health conditions: ### Dermatological Conditions The combination has received approval from Health Canada for claims related to eczema and atopic dermatitis under the brand name PROBIAL DERM®[8]. The efficacy is partly attributed to its immunomodulatory properties, particularly by increasing IL-10 production while reducing pro-inflammatory cytokines such as IL-13 and IL-17[8]. ### Allergic Conditions A pilot study showed that this probiotic combination administered twice daily for 8 weeks might reduce symptom scores and improve quality of life in patients with chronic spontaneous urticaria (CSU) who remain symptomatic despite antihistamine therapy[2][4]. ### Respiratory Health The combination has shown promising results in asthma management. The Probiotics in Pediatric Asthma Management (PROPAM) study demonstrated that this probiotic mixture significantly reduced the number of asthmatic exacerbations in children[7]. ### Immune Modulation The two strains have demonstrated beneficial immunomodulatory activity that is enhanced when used in combination. They can decrease the secretion of pro-inflammatory cytokines and increase the production of interleukin-10 (IL-10), which is a powerful inhibitor of pro-inflammatory cytokines[5]. ## Mechanism of Action The therapeutic benefits of this probiotic combination appear to be primarily through immune modulation: 1. **Anti-inflammatory effects**: The combination decreases the secretion of pro-inflammatory cytokines by peripheral blood mononuclear cells (PBMCs)[5]. 2. **IL-10 production**: There is an "intense increase" in the production of interleukin-10, which inhibits pro-inflammatory cytokines such as IL-4 and IL-5[5]. 3. **Synergistic effect**: The amount of IL-10 is higher when PBMCs are stimulated with both strains simultaneously, suggesting a synergistic effect[5]. 4. **Inhibition of specific pro-inflammatory cytokines**: The probiotic strains can inhibit the secretion of TGF-beta, IL-13, and IL-17[5]. 5. **Anti-pathogenic activity**: Particularly against Staphylococcus aureus and Escherichia coli[8][9]. The combination appears to be safe, with no reported side effects during clinical studies[2].

Brand names

PROBIAL DERM®