Drug intelligence / Profile preview

bifidobacterium longum

Development stage
Phase 1
Lead developer
Morinaga Milk Industry
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

bifidobacterium longum is a live probiotic bacterial drug candidate and microbiome therapeutic consisting of the species *Bifidobacterium longum*. It is being studied primarily as an orally administered microbial therapy intended to modulate the gut microbiota, strengthen epithelial barrier function, reduce inflammatory signaling, and alter host immune and metabolic responses through production of microbial metabolites and interactions with mucosal immune pathways. The exact pharmacology is strain-dependent, and the literature provided includes use in obesity-related metabolic dysfunction, atopic dermatitis models, nonalcoholic steatohepatitis, ulcerative colitis, chronic kidney disease-related uremic toxin reduction, constipation, migraine, ovarian cancer-associated paraneoplastic thrombocythemia, and other exploratory settings. Because the queried name refers to the species broadly rather than a single proprietary strain, it should be treated as a nonspecific live biotherapeutic/probiotic entity rather than one uniquely defined commercial asset.

Brand names
昶乐康
Other names
Bifidobacterium longum长双歧杆菌
02

Targets

MUC2 (Mucin-2)

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