Bifidobacterium longum BB536

Bifidobacterium longum BB536 is a clinically effective, well-established multifunctional probiotic strain originally isolated from a healthy infant. It is classified as a human-residential bifidobacteria (HRB) and has been used for over 50 years in humans to alleviate gastrointestinal, immunological, and infectious diseases. The strain produces lactic and acetic acid in the gut and is known for its ability to colonize the human intestine effectively[1][2][4]. Its primary mechanism of action involves modulation of the gut microbiota, enhancement of intestinal barrier function, production of beneficial metabolites (such as short-chain fatty acids), and immune system modulation[1][4]. Clinical studies have shown benefits in improving chronic constipation in elderly individuals[1], reducing symptoms of irritable bowel syndrome (IBS) in children[4], alleviating allergic symptoms such as Japanese cedar pollen allergy[5], supporting gut health after antibiotic or radiation exposure[5], and maintaining general digestive health. The strain is non-pathogenic, non-toxigenic, Generally Recognized As Safe (GRAS) by the FDA for use in foods including infant formula powder[3][6]. It is developed and manufactured by Morinaga Milk Industry.

Brand names

Probiotic-Pro BB536

Other names

Bifidobacterium longum subsp. longum BB536B. longum BB536