Drug intelligence / Profile preview

Bifidobacterium longum P26

Development stage
Preclinical
Lead developer
PBLbiolab
Modality
Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Bifidobacterium longum P26 is a specific strain of probiotic bacteria isolated from the stools of healthy human volunteers. Preclinical research in mice has shown that this strain, when administered orally, can alleviate symptoms of colitis and associated depression/anxiety-like behaviors induced by pathogenic bacteria such as Clostridioides difficile and Clostridium symbiosum. [1] The proposed mechanism of action involves the suppression of pathogenic bacterial growth and the reduction of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β), in both the colon and the hippocampus. [1] Research publications affiliate the work with Kyung Hee University and PBLbiolab Inc. [1, 6] A patent application has been filed that includes this specific strain under the accession number KCCM 13444P. [3]

Other names
Bifidobacterium longum strain P26KCCM 13444PKCCM13444PKCCM-13444P
02

Targets

IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)

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