Drug intelligence / Profile preview

bifidobacterium tetrad live bacteria tablet placebo + helicobacter pylori quadruple eradication therapy-Hangzhou Grand Biologic Pharmaceutical, Inc.-Helicobacter pylori infection

Development stage
Unknown
Lead developer
Hangzhou Grand Biologic Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

This combination regimen is used as the control arm in clinical trials conducted by Hangzhou Grand Biologic Pharmaceutical, Inc. to evaluate the efficacy of the probiotic Si Lian Kang. It consists of a starch-based placebo tablet, designed to mimic the Bifidobacterium tetrad live bacteria formulation, administered in conjunction with a standard bismuth-containing quadruple therapy (BQT) for the eradication of Helicobacter pylori infection. The BQT component includes esomeprazole (a proton pump inhibitor), amoxicillin and furazolidone (antibiotics), and bismuth potassium citrate. This regimen is intended to treat H. pylori infection while serving as a comparator to assess whether the addition of active probiotics can reduce the incidence of adverse reactions, such as nausea and diarrhea, and improve overall eradication rates.

Brand names
Si Lian KangA Mo XianLi Zhu De Le
02

Targets

ATP4A (Potassium–transporting ATPase alpha chain 1)PBP (Penicillin-binding protein family)DNA

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