BIIE 0426

BIIE 0426 is a pharmacological agent that functions as a Neuropeptide Y receptor Y2 (Y2R) antagonist. It is under investigation for its potential therapeutic role in treating obesity and metabolic syndrome, particularly those exacerbated by chronic stress in conjunction with a high-fat/high-sugar diet. By inhibiting the Y2R pathway, BIIE 0426 aims to counteract fat accumulation and alleviate associated metabolic complications, including abdominal obesity, inflammation, hyperlipidemia, hyperinsulinemia, glucose intolerance, hepatic steatosis, and hypertension. The proposed route of administration is local intra-fat.