Drug intelligence / Profile preview

Bilateral Quadratus Lumborum Block

Development stage
Unknown
Lead developer
Mahidol University
Modality
Small Molecules
Administration
Regional Nerve Block
01

Overview

Bilateral Quadratus Lumborum Block (QLB) is a regional anesthetic technique utilized for postoperative pain management, particularly following abdominal surgeries such as cesarean sections. In the clinical trial context provided by Mahidol University, the procedure involves the bilateral administration of a local anesthetic, specifically 0.25% bupivacaine, into the fascial plane surrounding the quadratus lumborum muscle. This technique facilitates the spread of the anesthetic into the paravertebral space, targeting the T5-L1 nerve branches to provide both somatic and visceral analgesia. The primary goal of the Bilateral QLB is to provide effective regional pain relief, thereby reducing the requirement for systemic opioids and minimizing associated side effects such as nausea, vomiting, and pruritus, while supporting earlier postoperative mobilization and recovery.

Other names
QLBQuadratus Lumborum BlockBilateral QLBBilateral Quadratus Lumborum Block-Mahidol University-postoperative pain
02

Targets

NaV (Voltage-gated sodium channels)

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