BIM-43004-1

BIM-43004-1 is a **novel synthetic analog of peptide YY (PYY) (22-36)**, developed as a **selective agonist of the neuropeptide Y2 receptor**. It specifically binds to Y2 receptors found on human pancreatic cancer cells, resulting in a decrease in intracellular cyclic AMP (cAMP) levels and suppression of tumor growth in vivo[1]. As a Y2 receptor agonist, BIM-43004-1 was shown to decrease the growth of human pancreatic cancer xenografts in mice by 60.5% compared to control, and to reduce intracellular cAMP in these cells by over 50%. Its actions are distinct from native PYY but leverage similar biological pathways, impacting tumor biology as well as gastrointestinal functions[1][5].