Drug intelligence / Profile preview

bimatoprost + travoprost + timolol

Development stage
Discontinued
Lead developer
Allergan
Modality
Small Molecules
Administration
Ophthalmic
01

Overview

Bimatoprost + travoprost + timolol is a hypothetical fixed-dose combination of three agents used to lower intraocular pressure in conditions such as open-angle glaucoma and ocular hypertension. Bimatoprost and travoprost are both prostaglandin analogs that increase the outflow of aqueous humor from the eye, thereby reducing intraocular pressure. Timolol is a non-selective beta-adrenergic blocker that decreases aqueous humor production, also resulting in reduced intraocular pressure. While fixed combinations of bimatoprost/timolol and travoprost/timolol are approved and widely used for glaucoma management, there is no evidence that a triple combination product containing all three (bimatoprost, travoprost, and timolol) exists or has been developed or marketed[1][3][5]. Each component acts via distinct but complementary mechanisms to achieve additive IOP-lowering effects.

02

Targets

PTGFR (Prostaglandin F2 alpha receptor)ADRB1 (β1)

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