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binaprofen
- Development stage
- Phase 2
- Lead developer
- Dalian Tianyu Pharmaceutical
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Binaprofen is a novel small molecule non-steroidal anti-inflammatory drug (NSAID) developed by Dalian Tianyu Pharmaceutical. Specifically developed as binaprofen sodium for intravenous injection, it is classified as a Category 1.1 innovative drug in China. The drug is primarily indicated for the management of moderate to severe postoperative pain. Its mechanism of action involves the non-selective inhibition of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. By inhibiting these enzymes, binaprofen blocks the conversion of arachidonic acid into pro-inflammatory prostaglandins, thereby exerting analgesic and anti-inflammatory effects. It has progressed through Phase 3 clinical trials to evaluate its efficacy and safety in surgical settings.
- Other names
- binaprofen sodium比那洛芬
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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