Drug intelligence / Profile preview

Biofil-AB

Development stage
Phase 1
Lead developer
Eucare Pharmaceuticals
Modality
Drug Delivery Systems, Small Molecules
Administration
Topical
01

Overview

**BioFil-AB** is a sterile topical wound-care formulation from Eucare containing fish-derived type I collagen particles with mupirocin 2% w/w and metronidazole 1% w/w. Mupirocin inhibits bacterial isoleucyl-tRNA synthetase and thereby suppresses protein synthesis, principally targeting susceptible gram-positive organisms including *Staphylococcus aureus*. Metronidazole is reduced in susceptible anaerobic microorganisms to reactive intermediates that damage microbial DNA. The lyophilized collagen matrix supports a moist wound environment, granulation tissue formation, and epithelialization. It is marketed in India for infected and chronic wounds, including diabetic foot ulcers, pressure ulcers, venous ulcers, traumatic wounds, and surgical wounds.

Brand names
BioFil-AB
Other names
mupirocin + metronidazole + collagenmupirocin + metronidazole + collagen peptide
02

Targets

bacterial dsDNA (Bacterial double-stranded DNA)IleRS (Isoleucyl-tRNA synthetase)

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