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BioFresh Clean S
- Development stage
- Unknown
- Lead developer
- Novones
- Modality
- Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Oral
01
Overview
BioFresh Clean S is an enzyme-based lozenge product developed by Novozymes A/S (now part of the Novonesis group) for the prevention and control of dental plaque and biofilm formation. The product contains a combination of three matrix-degrading enzymes: deoxyribonuclease (DNase), mutanase, and beta-glucanase. These enzymes work synergistically to disrupt the extracellular matrix of dental biofilms; DNase hydrolyzes phosphodiester linkages in extracellular DNA (eDNA), while mutanase and beta-glucanase cleave specific glycosidic bonds in polysaccharides. Designed as an adjunct to mechanical plaque removal, BioFresh Clean S has been evaluated in randomized controlled trials for its ability to reduce de novo plaque accumulation and gingivitis in healthy adults without causing adverse effects.
- Brand names
- BioFresh Clean S
- Other names
- enzyme-containing lozengesDNase + mutanase + beta-glucanase lozenge
02
Targets
DNAα-1,3-glucan
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