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Drug intelligence / Profile preview
BioResponse-DIM
- Development stage
- Unknown
- Lead developer
- BioResponse
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
BioResponse-DIM is a microencapsulated, absorption-enhanced formulation of diindolylmethane (DIM), a phytonutrient found in cruciferous vegetables. It is being evaluated as a non-surgical intervention for cervical intraepithelial neoplasia (CIN), particularly high-grade lesions (CIN 2/3). DIM acts by modulating estrogen metabolism, specifically increasing the ratio of 2-hydroxyestrone to 16-alpha-hydroxyestrone, which is associated with reduced risk of estrogen-dependent cancers. Additionally, it exhibits anti-proliferative, anti-angiogenic, and pro-apoptotic properties in HPV-transformed cervical cells. The clinical development for CIN has been led by investigators at New York Presbyterian Hospital.
- Brand names
- BioResponse-DIM
- Other names
- diindolylmethaneDIM3,3'-diindolylmethanedi indolylmethane
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)AHR (Aryl hydrocarbon receptor)CYP1A1 (Cytochrome P450 1A1)CYP1A2 (Cytochrome P450 1A2)NF-κB
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