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Bios Three
- Development stage
- Unknown
- Lead developer
- Toa Pharmaceuticals
- Modality
- Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Bios Three is a probiotic combination product developed by Toa Pharmaceutical, containing three symbiotic bacterial strains: *Enterococcus faecium* T-110 (lactic acid bacteria), *Clostridium butyricum* TO-A (butyric acid bacteria), and *Bacillus mesentericus* TO-A (saccharolytic bacteria). These strains work synergistically to regulate intestinal flora; *Bacillus mesentericus* promotes the growth of *Enterococcus faecium*, which produces lactic acid and lowers intestinal pH, thereby facilitating the growth of *Clostridium butyricum*. *Clostridium butyricum* produces butyric acid, a key energy source for colonic epithelial cells that supports intestinal barrier function. The product is approved in Japan for the treatment of gastrointestinal symptoms such as diarrhea, constipation, and abdominal bloating. It is also being investigated in clinical trials for its potential to modulate the intestinal and vaginal microbiota in pregnant women to prevent pregnancy-associated complications.
- Brand names
- Bios ThreeBio-Threeビオスリー
- Other names
- Enterococcus faecium + Clostridium butyricum + Bacillus mesentericus
02
Targets
IEB (Colonic epithelial barrier and mucus layer)
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