Drug intelligence / Profile preview

biotin

Development stage
Phase 3
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral, Intramuscular, Intravenous
01

Overview

Biotin is a water-soluble B-complex vitamin (Vitamin B7) essential for normal cellular function and metabolism. It acts as a coenzyme for carboxylases involved in the synthesis of fatty acids, gluconeogenesis (glucose production), amino acid catabolism (especially branched-chain amino acids), and other metabolic pathways[1][5][6]. Biotin is required for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide. It also plays roles in cell signaling and epigenetic regulation[6]. Biotin deficiency is rare but can occur due to malnutrition or certain medical conditions; supplementation treats or prevents deficiency. While commonly marketed for hair loss and brittle nails—and sometimes used in high doses experimentally for multiple sclerosis—there is limited evidence supporting its effectiveness beyond treating deficiency[1][3][4].

Brand names
AppearexCyto B7Hair, Skin, Nails
Other names
Vitamin B7Coenzyme RFactor SVitamin HW factord-(+)-Biotin
02

Targets

ACC (Acetyl-CoA Carboxylase 1)PROC (Protein C)MCCA (Methylcrotonoyl-CoA carboxylase subunit alpha)HLCS (Holocarboxylase synthetase)PCCA (Propionyl-CoA carboxylase alpha subunit)

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