Drug intelligence / Profile preview

biphasic human insulin 30

Development stage
Unknown
Lead developer
Novo Nordisk
Modality
Recombinant Proteins and Enzymes
Administration
Subcutaneous
01

Overview

Biphasic human insulin 30 is a pre-mixed (biphasic) formulation containing two types of recombinant human insulins in fixed proportions—typically **30% regular (short-acting) human insulin and 70% isophane (NPH; intermediate-acting) human insulin**. This combination provides both rapid onset and prolonged duration of action to help control blood glucose levels in people with diabetes mellitus. The short-acting component covers post-meal glucose spikes while the intermediate-acting component maintains basal glycemic control between meals and overnight. Biphasic insulins are administered subcutaneously—usually twice daily before meals—and are used primarily for the management of type 1 and type 2 diabetes mellitus[1][3][5][9]. The mechanism of action involves mimicking endogenous pancreatic insulin by promoting cellular uptake of glucose from the bloodstream into tissues such as muscle and fat while inhibiting hepatic glucose production.

Brand names
Humulin 30/70Novolin ge 30/70Mixtard 30Mixtard30Mixtard-30Huminsulin 30/70Lupsulin M 30/70Wosulin 30/70Insugen 30/70Human Mixtard 30/70Humstard 30/70Actraphane HMHuman Mixact 30/70
Other names
biphasic human insulin (BHI) 30/70
02

Targets

INSR (Insulin receptor)

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