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biphasic porous nanocrystalline calcium phosphate
- Development stage
- Preclinical
- Lead developer
- National Engineering Research Center for Biomaterials
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Nanoparticles → Drug Delivery Systems
- Administration
- Implantation (surgical), Local Application To Defect Site During Surgery Or Procedure[6][7][8]
01
Overview
Biphasic porous nanocrystalline calcium phosphate (BpNcCaP) is a synthetic bone graft material composed of two primary phases—hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP)—in a nanocrystalline form with a highly porous structure. The combination of these phases aims to balance bioresorbability and mechanical stability. The nanoscale crystallinity mimics natural bone mineral more closely than conventional microcrystalline forms, enhancing protein adsorption, cell attachment, osteogenic differentiation, and new bone formation. Its high porosity further supports vascularization and tissue ingrowth. BpNcCaP is primarily developed for use in regenerative medicine as a scaffold for bone defect repair and reconstruction in orthopedic and dental applications. It acts mainly through osteoconduction (providing a scaffold for new bone growth) and demonstrates some osteoinductive properties due to its nanotopography[6][7][8]. Developers include academic research centers such as the National Engineering Research Center for Biomaterials at Sichuan University[7].
- Other names
- biphasic porous nanocrystalline calcium phosphateBpNcCaPporous biphasic nanocrystalline calcium phosphateBCP-N
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